Introduction for 35:2
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منابع مشابه
Dmd055665 352..360
The cystolic sulfotransferse 1C3 (SULT1C3) gene was identified by computational analysis of the human genome and suggested to contain duplications of its last two exons (7a/b and 8a/b). Although the SULT1C3 isoform containing the more downstream exons 7b and 8b (SULT1C3d) has been expressed in Escherichia coli, crystallized, and characterized for activity, there is currently no evidence that SU...
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Diabetes Mellitus is a metabolic disorder characterized by the presence of hyperglycaemia due to defective insulin secretion, insulin action or both. The estimated number of people with diabetes registered in India was 50.8 million in the 2010 and diabetes will be affecting 87 million persons by 2030. A prospective cross-sectional study was conducted in the outpatient Department of Medicine in ...
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Nonsense-mediated mRNA decay (NMD) represents a highly conserved RNA surveillance mechanism through which mRNA transcripts bearing premature termination codons (PTCs) are selectively degraded to maintain transcriptomic fidelity in the cell. Numerous in vitro studies have demonstrated the importance of the NMD pathway; however, evidence supporting its physiological necessity has only just starte...
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This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to the enzyme inhibition because it was not fully characterized in previous works. Bambuterol and MONO enanti...
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Crizotinib (Xalkori) is an orally available potent inhibitor of multiple tyrosine kinases, including anaplastic lymphoma kinase and mesenchymal-epithelial transition factor. Objectives of the present study were as follows: 1) to characterize crizotinib time-dependent inhibition (TDI) potency for CYP3A in human liver microsomes (HLM) and cryopreserved human hepatocytes suspended in human plasma ...
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ژورنال
عنوان ژورنال: Journal of Media Ethics
سال: 2020
ISSN: 2373-6992,2373-700X
DOI: 10.1080/23736992.2020.1736376